AUTHOR=Willrodt Ann-Helen , Salabarria Ann-Charlott , Schineis Philipp , Ignatova Desislava , Hunter Morgan Campbell , Vranova Martina , Golding-Ochsenbein Alexandra M. , Sigmund Elena , Romagna Annatina , Strassberger Verena , Fabbi Marina , Ferrini Silvano , Cursiefen Claus , Neri Dario , Guenova Emmanuella , Bock Felix , Halin Cornelia TITLE=ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00759 DOI=10.3389/fimmu.2019.00759 ISSN=1664-3224 ABSTRACT=
Activated leukocyte cell adhesion molecule (ALCAM, CD166) is a cell adhesion molecule of the immunoglobulin superfamily and has been implicated in diverse pathophysiological processes including T cell activation, leukocyte trafficking, and (lymph)angiogenesis. However, exploring the therapeutic potential of ALCAM blockade in immune-mediated inflammatory disorders has been difficult due to the lack of antibodies with blocking activity toward murine ALCAM. In this study, we identified and characterized a monoclonal antibody with high affinity and specificity for murine ALCAM. This antibody reduced