AUTHOR=Shao Liang , Pan Shan , Zhang Qiu-ping , Jamal Muhammad , Chen Lu-hua , Yin Qian , Wu Ying-jie , Xiong Jie , Xiao Rui-jing , Kwong Yok-lam , Zhou Fu-ling , Lie Albert K. W. 

TITLE=An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease

JOURNAL=Frontiers in Immunology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01233

DOI=10.3389/fimmu.2019.01233

ISSN=1664-3224

ABSTRACT=Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and nonmalignant hematological diseases. However, graft-versus-host disease, one of the main complications after allo-HSCT, remains the major reason for morbidity and nonrelapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a nonredundant role in the pathophysiology of graft-versus-host disease (GVHD). In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.