AUTHOR=Meira Cássio Santana , Santos Emanuelle De Souza , Santo Renan Fernandes do Espírito , Vasconcelos Juliana Fraga , Orge Iasmim Diniz , Nonaka Carolina Kymie Vasques , Barreto Breno Cardim , Caria Alex Cleber Improta , Silva Daniela Nascimento , Barbosa-Filho José Maria , Macambira Simone Garcia , Moreira Diogo Rodrigo Magalhães , Soares Milena Botelho Pereira TITLE=Betulinic Acid Derivative BA5, Attenuates Inflammation and Fibrosis in Experimental Chronic Chagas Disease Cardiomyopathy by Inducing IL-10 and M2 Polarization JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01257 DOI=10.3389/fimmu.2019.01257 ISSN=1664-3224 ABSTRACT=
Chronic Chagas disease cardiomyopathy (CCC) is a major cause of heart disease in Latin America and treatment for this condition is unsatisfactory. Here we investigated the effects of BA5, an amide semi-synthetic derivative betulinic acid, in a model of CCC. Mice chronically infected with