AUTHOR=Denorme Frederik , Vanhoorelbeke Karen , De Meyer Simon F. 

TITLE=von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

JOURNAL=Frontiers in Immunology

VOLUME=Volume 10 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.02884

DOI=10.3389/fimmu.2019.02884

ISSN=1664-3224

ABSTRACT=Von Willebrand factor (VWF) and platelets are key mediators of normal hemostasis. At sites of vascular injury, VWF recruits platelets via binding to the platelet receptor glycoprotein Ib (GPIb). Over the past decades, it has become clear that many hemostatic factors, including VWF and platelets, are also involved in inflammatory processes, forming intriguing links between hemostasis, thrombosis and inflammation. The so-called ‘thrombo-inflammatory’ nature of the VWF-platelet axis becomes increasingly recognized in different cardiovascular pathologies, making it a potential therapeutic target to interfere with both thrombosis and inflammation. In this review, we discuss the current evidence for the thrombo-inflammatory activity of VWF with a focus on the VWF-GPIb axis and discuss its implications in the setting of ischemic stroke.