AUTHOR=Scott David W. , Pratt Kathleen P. 

TITLE=Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies

JOURNAL=Frontiers in Immunology

VOLUME=Volume 10 - 2019

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.03078

DOI=10.3389/fimmu.2019.03078

ISSN=1664-3224

ABSTRACT=Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function.  Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.