AUTHOR=Tang Yanyan , Zhang Ping , Wang Yumin , Wang Jinpeng , Su Min , Wang Ying , Zhou Lianqing , Zhou Jumei , Xiong Wei , Zeng Zhaoyang , Zhou Yujuan , Nie Shaolin , Liao Qianjin 

TITLE=The Biogenesis, Biology, and Clinical Significance of Exosomal PD-L1 in Cancer

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00604

DOI=10.3389/fimmu.2020.00604

ISSN=1664-3224

ABSTRACT=The exosome serves as a trafficking vehicle for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells by exosomal PD-L1. Here, we summerize the biogenesis and transport process of exosomal PD-L1. Then, we focus on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlight the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we discuss the new challenges faced in researching and utilizing exosomal PD-L1. This review may shed light on the exosomal PD-L1 from the bench to the clinic.