AUTHOR=Wang Changgang , Feng Haoran , Cheng Xi , Liu Kun , Cai Dongli , Zhao Ren 

TITLE=Potential Therapeutic Targets of B7 Family in Colorectal Cancer

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00681

DOI=10.3389/fimmu.2020.00681

ISSN=1664-3224

ABSTRACT=PD-1/PD-L1 pathway blockade has impressively benefited cancer patients with a wide spectrum of tumors. However, its efficacy in CRC is modest, and only a small subset of patients benefits from approved checkpoint inhibitors. Newer checkpoints that target additional immunomodulatory pathways are becoming necessary to activate durable antitumor immune responses in patients with CRC. In this review, we evaluated the mRNA expression of all 10 reported B7 family members in human CRC by retrieving and analyzing the TCGA database and reviewed the current understanding of the top three B7 family checkpoint molecules (B7-H3, VISTA and HHLA2) with the highest mRNA expression, introducing them as putative therapeutic targets in CRC.