AUTHOR=Garelli Colton J. , Refat Maggi Ahmed , Nanaware Padma P. , Ramirez-Ortiz Zaida G. , Rashighi Mehdi , Richmond Jillian M. 

TITLE=Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01353

DOI=10.3389/fimmu.2020.01353

ISSN=1664-3224

ABSTRACT=Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal-epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.