AUTHOR=Ye Mengling , Xie Minghong , Zhu Jie , Wang Chen , Zhou Rui , Li Xiaoqing 

TITLE=LPS-Inducible lncRNA TMC3-AS1 Negatively Regulates the Expression of IL-10

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01418

DOI=10.3389/fimmu.2020.01418

ISSN=1664-3224

ABSTRACT=Long non-coding RNAs (lncRNAs) are essential regulators of the inflammatory response, especially for transcriptional regulation of inflammatory genes. It has been reported that the expression of TMC3-AS1 is increased following LPS stimulation. However, the potential function of TMC3-AS1 in immunity is largely unknown. Herein, we report a specific role for TMC3-AS1 in the regulation of inflammatory genes expression. TMC3-AS1 negatively regulates the expression of IL10 in intestinal epithelial cells and macrophages. Mechanistically, TMC3-AS1 may interact with p65 in the nucleus, preventing p65 from binding to the κB consensus site within IL10 promoter. These findings suggest that TMC3-AS1 may function as an important regulator in the innate immune response.