AUTHOR=Contini P. , Murdaca Giuseppe , Puppo Francesco , Negrini Simone 

TITLE=HLA-G Expressing Immune Cells in Immune Mediated Diseases

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01613

DOI=10.3389/fimmu.2020.01613

ISSN=1664-3224

ABSTRACT=HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G+CD4+, HLA-G+CD8+ and HLA-G+CD4+ regulatory T cells with immune-suppressive and immunoregulatory functions are present in small amounts in physiologic conditions. Increased amounts of these HLA-G positive cells have been detected in several immune mediated diseases, like multiple sclerosis, psoriasis, systemic lupus erythematosus and systemic sclerosis. Further investigations are required in order to define a possible role of HLA-G positive immune cells in the pathogenesis of immune mediated diseases.