AUTHOR=Chao Min , Liu Nan , Sun Zhichuan , Jiang Yongli , Jiang Tongtong , Xv Meng , Jia Lintao , Tu Yanyang , Wang Liang 

TITLE=TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.592080

DOI=10.3389/fimmu.2020.592080

ISSN=1664-3224

ABSTRACT=<p>Gliomas are brain and spinal cord malignancies characterized by high malignancy, high recurrence and poor prognosis, the underlying mechanisms of which remain largely elusive. Here, we found that the Sry-related high mobility group box (Sox) family transcription factor, Sox9, was upregulated and correlated with poor prognosis of clinical gliomas. Sox9 promotes migration and invasion of glioma cells and <italic>in vivo</italic> development of xenograft tumors from inoculated glioma cells. Sox9 functions downstream of the transforming growth factor-β (TGF-β) pathway, in which TGF-β signaling prevent proteasomal degradation of the Sox9 protein in glioma cells. These findings provide novel insight into the wide interplay between TGF-β signaling and oncogenic transcription factors, and have implications for targeted therapy and prognostic assessment of gliomas.</p>