AUTHOR=Van Damme Karel F. A. , Tavernier Simon , Van Roy Nele , De Leeuw Elisabeth , Declercq Jozefien , Bosteels Cédric , Maes Bastiaan , De Bruyne Marieke , Bogaert Delfien , Bosteels Victor , Hoste Levi , Naesens Leslie , Maes Piet , Grifoni Alba , Weiskopf Daniela , Sette Alessandro , Depuydt Pieter , Van Braeckel Eva , Haerynck Filomeen , Lambrecht Bart N. 

TITLE=Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.596761

DOI=10.3389/fimmu.2020.596761

ISSN=1664-3224

ABSTRACT=<p>The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.</p>