AUTHOR=Tavasolian Fataneh , Rashidi Mohsen , Hatam Gholam Reza , Jeddi Marjan , Hosseini Ahmad Zavaran , Mosawi Sayed Hussain , Abdollahi Elham , Inman Robert D. 

TITLE=HLA, Immune Response, and Susceptibility to COVID-19

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.601886

DOI=10.3389/fimmu.2020.601886

ISSN=1664-3224

ABSTRACT=The contagious severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) that appeared in December 2019 has precipitated the global pandemic Coronavirus Disease 2019 (COVID-19)  However, in many parts of African fewer than expected cases of COVID-19, with lower rates of mortality, have been reported. We suggest a theory regarding human leukocyte antigen (HLA) antigens and presentation of viral peptides which could be associated with susceptibility vs resistance to SARS-CoV-2 infections.

Keywords: COVID-19, HLA antigens, Original Antigenic Sin