AUTHOR=Hou Wen , Wu Xiaoli 

TITLE=Diverse Functions of γδ T Cells in the Progression of Hepatitis B Virus and Hepatitis C Virus Infection

JOURNAL=Frontiers in Immunology

VOLUME=Volume 11 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.619872

DOI=10.3389/fimmu.2020.619872

ISSN=1664-3224

ABSTRACT=Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are primary risk factors for a wide spectrum of liver diseases that severely affect human health. The liver is an immunological organ that has an abundance of immune cells. Thus, various innate or adaptive immune cells are involved in the progression of HBV or HCV infection. Among those cells, a unique kind of immune cell, γδ T cells, contribute to promote or inhibit the progression of liver diseases. To reveal the diverse roles of γδ T cells in HBV or HCV infection, the properties and functions of these cells in human and mouse models were analyzed. Here, we briefly describe the characteristics and function of γδ T cells subsets in liver diseases. Then, we fully discuss the diverse roles of γδ T cells in the progression of HBV or HCV infection, including stages of acute infection, chronic infection, liver cirrhosis, and hepatocellular carcinoma. Finally, the function and existing problems of γδ T cells in HBV or HCV infection are summarized. To better understand the function of γδ T cells during progression of HBV and HCV infection is helpful for the treatment of virus infection.