AUTHOR=Pei Minghang , Liu Xinshu , Yang Peizeng , Zhao Chan , Gao Fei , Qu Yi , Liang Anyi , Xiao Junyan , Zhang Meifen 

TITLE=Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet’s Uveitis

JOURNAL=Frontiers in Immunology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.589639

DOI=10.3389/fimmu.2021.589639

ISSN=1664-3224

ABSTRACT=<p>Interleukin (IL)33, a member of the IL1 superfamily, functions as a nuclear factor and mediates biological effects by interacting with the ST2 receptor. Recent studies have described IL33 as an emerging pro-inflammatory cytokine in the immune system, and <italic>IL33</italic>/<italic>ST2</italic> gene polymorphisms have been implicated in the pathogenesis of various immune diseases. However, the underlying mechanisms of <italic>IL33/ST2</italic> in Behcet’s disease (BD) remain to be defined. Here, we investigated the association between <italic>IL33/ST2</italic> gene polymorphisms and BD in 585 BD uveitis (BDU) patients and 834 healthy controls using Agena MassARRAY iPLEX platform. We found that rs3821204 was associated with the development of BDU. Moreover, the frequency of rs2210463 G allele was lower in patients with genital involvement. Association analysis revealed a much greater genetic difference between complete-type and incomplete-type BD groups, including three SNPs (rs7044343, rs1048274, and rs2210463). Our findings suggest that <italic>IL33/ST2</italic> gene polymorphisms are involved in the pathogenesis of BDU. Different genetic backgrounds may exist in complete-type and incomplete-type BD patients.</p>