AUTHOR=Wu Jian , Shen Jiawei , Han Ying , Qiao Qinghua , Dai Wei , He Bangshun , Pang Rongrong , Zhao Jun , Luo Tao , Guo Yanju , Yang Yang , Wu Qiuyue , Jiang Weijun , Zhang Jing , Zhang Mingchao , Li Na , Li Weiwei , Xia Xinyi 

TITLE=Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.598799

DOI=10.3389/fimmu.2021.598799

ISSN=1664-3224

ABSTRACT=A comprehensive understanding of the dynamic changes in interleukin-6 (IL6) levels is essential for monitoring and treating SARS-Cov-2 infected patients. By analyzing the correlations between IL6 levels and health conditions, underlying diseases, several key laboratory detection indexes, and the prognosis of 1,473 COVID-19 patients, the role of IL6 during a SARS-CoV-2 infection was demonstrated. Our results indicated that IL6 levels were closely related to age, sex, body temperature, oxygen saturation of blood (SpO2), and underlying diseases. As a stable indicator, the changes in IL6 levels could indicate the inflammatory conditions during a virus infection. Two specific treatments; i.e., tocilizumab and convalescent plasma therapy, decreased the level of IL6 and relieved inflammation. Convalescent plasma therapy has an important role in critical COVID-19 patient therapy. We also found that patients with IL6 levels that were 30-fold higher than the normal level had a poor prognosis compared to patients with lower levels of IL6.