AUTHOR=Bacigalupo Andrea , Innocenti Idanna , Rossi Elena , Sora Federica , Galli Eugenio , Autore Francesco , Metafuni Elisabetta , Chiusolo Patrizia , Giammarco Sabrina , Laurenti Luca , Benintende Giulia , Sica Simona , De Stefano Valerio 

TITLE=Allogeneic Hemopoietic Stem Cell Transplantation for Myelofibrosis: 2021

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.637512

DOI=10.3389/fimmu.2021.637512

ISSN=1664-3224

ABSTRACT=The aim of this review is to update the current status of allogeneic hemopoietic stem cell transplants (HSCT) for patients with myelofibrosis. The manuscript will be divided in to the following sections. Indication for an allogeneic HSCT, as outlined in recent international guidelines. How to predict the outcome of HSCT, as suggested by prognostic risk scores, based on clinical, biological and transplant data. The choice of a transplant platform including the conditioning regimen, the stem cell source and GvHD prophylaxis. Poor graft function and graft failure. Monitoring disease control after HSCT with donor chimerism, driver mutations and hematologic data. Treatment of relapse.
We have made an effort to make this review as comprehensive and up to date as possible, and we hope it will provide some useful data for the clinicians.