AUTHOR=Fang Xiang-Zhi , Wang Ya-Xin , Xu Ji-Qain , He Ya-Jun , Peng Zhe-Kang , Shang You 

TITLE=Immunothrombosis in Acute Respiratory Dysfunction of COVID-19

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.651545

DOI=10.3389/fimmu.2021.651545

ISSN=1664-3224

ABSTRACT=COVID-19 is an acute, complex disorder that was caused by a new β-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on current reports, it was surprising that the characteristics of many patients with COVID-19 who fulfil the Berlin criteria for acute respiratry distress syndrme (ARDS), are not always like those of patients with typical ARDS and can change over time.While the mechanisms of COVID-19-related respiratory dysfunction in COVID-19 have not yet been fully elucidated. pulmonary microvascular thrombosis is involved is speculated to be involved. Considering that thrombosis is highly related to other inflammatory lung diseases, immunothrombosis, a two-way process that links coagulation and inflammation, seems to be involved in the pathophysiology of COVID-19, including respiratory dysfunction. Thus, the current manuscript will describe the proinflammatory milieu in COVID-19, summarize current evidence of thrombosis in COVID-19, and disscues possible interactions between these two.