AUTHOR=Liu Shuai , Zhao Keji 

TITLE=The Toolbox for Untangling Chromosome Architecture in Immune Cells

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.670884

DOI=10.3389/fimmu.2021.670884

ISSN=1664-3224

ABSTRACT=The code of life is not only encrypted in the sequence of DNA, but also the way it is organized into chromosomes. Chromosome architecture is gradually recognized as an important player in regulating cell activities (e.g., controlling spatiotemporal gene expression). In the past decade, the toolbox for elucidating genome structure has been expanding, providing an opportunity to explore this under charted territory. In this review, we will introduce the recent advances of approaches for mapping spatial organization of the genome, emphasizing on applying these techniques to immune cells, and try to bridge the chromosome structure with immune cell activities.