AUTHOR=Li Guanqun , Chen Hongze , Liu Liwei , Xiao Peng , Xie Yu , Geng Xinglong , Zhang Tao , Zhang Yang , Lu Tianqi , Tan Hongtao , Li Le , Sun Bei 

TITLE=Role of Interleukin-17 in Acute Pancreatitis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.674803

DOI=10.3389/fimmu.2021.674803

ISSN=1664-3224

ABSTRACT=Acute pancreatitis (AP) is a leading cause of death and commonly accompanied by systemic manifestations that are generally associated with a poor prognosis, making it a headache for clinicians. Many cytokines contribute to the damage of pancreatic tissue, also cause systemic injury. Interleukin-17 (IL-17) is a cytokine with potential effects in AP which plays a potential role. Specially, IL-17 has an important place in the immune response and cause interactions between different inflammatory mediators in AP-related microenvironment. In this literature review, the authors will discuss the existing academic understanding of IL-17 and the impacts of IL-17 in different cells(especially in acinar cell and immune system cells) in AP pathogenesis. The clinical significance and the mechanisms of IL-17 on AP deterioration are emphasized. The evidence suggests that inhibiting the IL-17 cytokine family could alleviate the pathogenic process of AP and accelerate the improvement or prevent the progression towards deterioration.