AUTHOR=Zhou Xiaoli , Zhou Ya-Na , Ali Ashaq , Liang Cuiqin , Ye Zhiqin , Chen Xiaomin , Zhang Qing , Deng Lihua , Sun Xinyi , Zhang Qian , Luo Jihong , Li Wei , Zhou Kun , Cao Shanshan , Zhang Xiaowei , Li Xiao-Dong , Zhang Xian-En , Cui Zongqiang , Men Dong TITLE=Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma JOURNAL=Frontiers in Immunology VOLUME=Volume 12 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.701295 DOI=10.3389/fimmu.2021.701295 ISSN=1664-3224 ABSTRACT=The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, without specifying the nature of the impairments. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months later, while discharged from the hospital on recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract, and the infection was also diagnosed in the aqueous humor through immune-staining by antibody against N protein and S protein of SARS-CoV-2. Considering the eye as immune privileged site, we speculate that SARS-CoV-2 survived in immune privileged sites in the eye and caused re-positive of SARS-CoV-2.