AUTHOR=Yang Keda , Wen Guangfu , Wang Jinpeng , Zhou Siming , Da Wacili , Meng Yan , Xue Yuchuan , Tao Lin TITLE=Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.711741 DOI=10.3389/fimmu.2021.711741 ISSN=1664-3224 ABSTRACT=

COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in addition to respiratory symptoms. Controlling the epidemic is only a phased victory, and the complication and sequelae of COVID-19 will need more attention in the post-epidemic era. We collected general information from over 1000 articles published in 2020 after the COVID-19 outbreak and systematically analyzed the complication and sequelae associated with eight major systems in COVID-19 patients caused by ACE2 intervention in the RAS regulatory axis. The autoimmune response induced by 2019-nCoV attacks and damages the normal tissues and organs of the body. Our research will help medical workers worldwide address COVID-19 complication and sequelae.