AUTHOR=Schaap-Johansen Anna-Lisa , Vujović Milena , Borch Annie , Hadrup Sine Reker , Marcatili Paolo TITLE=T Cell Epitope Prediction and Its Application to Immunotherapy JOURNAL=Frontiers in Immunology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.712488 DOI=10.3389/fimmu.2021.712488 ISSN=1664-3224 ABSTRACT=

T cells play a crucial role in controlling and driving the immune response with their ability to discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we focus on the currently available computational tools for epitope prediction, with a particular focus on tools aimed at identifying neoepitopes, i.e. cancer-specific peptides and their potential for use in immunotherapy for cancer treatment. This review will cover how these tools work, what kind of data they use, as well as pros and cons in their respective applications.