AUTHOR=Chen Yongyan , Cui Wenwen , Li Xiao , Yang Huan 

TITLE=Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.761981

DOI=10.3389/fimmu.2021.761981

ISSN=1664-3224

ABSTRACT=The intestinal barrier is mainly composed of mucosa and intestinal epithelial cells and is the first line of defense against pathogens. In inflammatory bowel disease (IBD), the intestinal mucosa and intestinal epithelial cells are severely damaged, and the commensal bacteria and the immune system are indispensable. At this time, the susceptibility of intestinal cells to bacteria is increased, and many commensal bacteria become pathogenic, stimulating a series of compensatory immune responses in the intestine. However, the immune response prevents the intestinal tract from restoring homeostasis, which in turn produces an uncontrollable inflammatory response. This article describes the protective mechanism of commensal bacteria in healthy people and the mechanism of commensal bacteria and immune response to the destruction of the intestinal barrier when IBD occurs. The treatment and prevention of IBD are also briefly summarized. New strategies to influence the colonization of commensal bacteria in the development of IBD and prevent the destruction of the intestinal barrier are needed.