AUTHOR=Zhang Lingshu , Chu Cong-Qiu 

TITLE=Gut Microbiota–Medication Interaction in Rheumatic Diseases

JOURNAL=Frontiers in Immunology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.796865

DOI=10.3389/fimmu.2021.796865

ISSN=1664-3224

ABSTRACT=Besides contribution to the development of rheumatic diseases, gut microbiota interact with anti-rheumatic drugs. Intestinal microbiota can directly metabolize many drugs and indirectly change drug metabolism through a complex multi-dimensional interaction with the host thus affecting individual response to drug therapy and adverse effects. The focus of the current review is to address recent advances and important progress in our understanding of how gut microbiota interact with anti-rheumatic drugs and provide perspectives on promoting precision treatment, drug discovery and better therapy for rheumatic diseases.