AUTHOR=Liu Chengxin , Yang Juhua , Huang Huiting , Zhan Shaofeng , Xia Xintian 

TITLE=Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1053914

DOI=10.3389/fimmu.2022.1053914

ISSN=1664-3224

ABSTRACT=The infection of Nocardia gipuzkoensis is a relatively uncommon form of pulmonary nocardiosis seen in clinical patients. In general, nocardiosis tends to occur in patients with immune deficiency. Here, we reported a 23-year-old female who was admitted to the hospital due to cough and sputum production increasing, diagnosed with bronchiectasis over 10 years. The Nocardia gipuzkoensis infection was identified by metagenomic next-generation sequencing (mNGS) and Whole Genome Sequencing (WGS). Imipenem/cilastatin and Compound Sulfamethoxazole Tablets (SMZ) were used to control the infection and the pulmonary inflammation subsided gradually.