AUTHOR=Huang Tingting , Liu Yankuo , Li Jiwei , Shi Bingbing , Shan Zhengda , Shi Zhiyuan , Yang Zhangru TITLE=Insights into prognosis and immune infiltration of cuproptosis-related genes in breast cancer JOURNAL=Frontiers in Immunology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1054305 DOI=10.3389/fimmu.2022.1054305 ISSN=1664-3224 ABSTRACT=Breast cancer (BC) has been ranking first in incidence and the leading cause of death among female cancers worldwide based on the latest report. Regulated cell death (RCD) plays a significant role in tumor initiation and provides an important target of cancer treatment. Cuproptosis, a novel form of RCD, is ignited by mitochondrial stress, particularly the lipoylated mitochondrial enzymes aggregation. However, the role of cuproptosis-related genes (CRGs) in tumor generation and progression remains unclear. In the present study, we utilized a variety of bioinformatics methods to explore the role of CRGs expression in tumor prognosis and immunity response. Our results indicated that CRGs expression is different in BC and normal breast tissues. Then we conducted the survival and cox regression analysis of these genes and found that upregulated PDHA1 expression was associated with worse endpoint of BC. Moreover, we also performed immune infiltration analysis of CRGs, and the result demonstrated that PDHA1 expression was closely related to the infiltration level of CD4+ memory T cell, macrophage M0 and M1 cell and mast cell in BC. Therefore, PDHA1 can be an independent prognostic biomarker and potential target for immunotherapy of BC.