AUTHOR=Liu Shiyu , Szatmary Peter , Lin Jing-wen , Wang Qiqi , Sutton Robert , Chen Lu , Liu Tingting , Huang Wei , Xia Qing TITLE=Circulating monocytes in acute pancreatitis JOURNAL=Frontiers in Immunology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.1062849 DOI=10.3389/fimmu.2022.1062849 ISSN=1664-3224 ABSTRACT=

Acute pancreatitis is a common gastrointestinal disease characterized by inflammation of the exocrine pancreas and manifesting itself through acute onset of abdominal pain. It is frequently associated with organ failure, pancreatic necrosis, and death. Mounting evidence describes monocytes - phagocytic, antigen presenting, and regulatory cells of the innate immune system - as key contributors and regulators of the inflammatory response and subsequent organ failure in acute pancreatitis. This review highlights the recent advances of dynamic change of numbers, phenotypes, and functions of circulating monocytes as well as their underling regulatory mechanisms with a special focus on the role of lipid modulation during acute pancreatitis.