AUTHOR=Gao Xiaofei , Song Yang , Lu Shuang , Hu Longyuan , Zheng Meiling , Jia Sujie , Zhao Ming 

TITLE=Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell Expansion

JOURNAL=Frontiers in Immunology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.799331

DOI=10.3389/fimmu.2022.799331

ISSN=1664-3224

ABSTRACT=<p>Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a promising therapeutic method for SLE. Here we showed that iron deficiency promotes Treg cell expansion by reducing ROS accumulation, improving the disease progression of pristane-induced lupus. Increased oxidative stress inhibits Treg cell differentiation by inducing cell apoptosis. Our data suggest that altering iron metabolism promotes Treg cell expansion by preventing oxidation-induced cell death, which may provide a potential therapeutic strategy for SLE.</p>