AUTHOR=Pan Yuhong , Cai Wenjun , Cheng Anchun , Wang Mingshu , Yin Zhongqiong , Jia Renyong 

TITLE=Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.829433

DOI=10.3389/fimmu.2022.829433

ISSN=1664-3224

ABSTRACT=The innate immune system is the first line of defense against pathogens including flaviviruses. Cell death plays an important role in limiting infection with pathogens. However, inflammatory cell death also results in the release of pro-inflammatory cytokines and cellular contents, which can cause severe inflammation. In this review, we focused on our current understanding of the innate immune response, inflammasome activation, inflammatory cell death pathways, and cytokine secretion during Dengue virus, West Nile virus, Zika virus, Japanese encephalitis virus and other flavivirus infections. We also discussed how the pathogenesis of these viruses affects these biological processes, which provides a scientific basis for understanding the pathogenesis of flavivirus and helps in developing effective antiviral therapies.