AUTHOR=Huang Jie , Liu Xinxin , Wei Yingying , Li Xinlu , Gao Shupei , Dong Lingli , Rao Xiaoquan , Zhong Jixin 

TITLE=Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.830863

DOI=10.3389/fimmu.2022.830863

ISSN=1664-3224

ABSTRACT=Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is a ubiquitously expressed protease presented either as a membrane-bound or soluble form. DPP4 cleaves dipeptide off from the N-terminal of its substrates, altering the bioactivity of its substrates. Subsequent studies reveal that DPP4 is also involved in various cellular processes by directly binding to a number of ligands, including adenosine deaminase, fibronectin, and caveolin-1. In recent years, many novel functions of DPP4, such as promoting fibrosis and mediating virus entry, have been discovered. Due to its implication in fibrotic response and immunoregulation, increasing studies are focusing on the potential role of DPP4 in inflammatory disorders. In this review, we will summarize the recent advances of DPP4 in immune regulation and autoimmune rheumatic disease.