AUTHOR=Matzinger Polly TITLE=Autoimmunity: Are we asking the right question? JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.864633 DOI=10.3389/fimmu.2022.864633 ISSN=1664-3224 ABSTRACT=

For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.