AUTHOR=Zhao Min , Tian Chang , Cong Shan , Di Xin , Wang Ke 

TITLE=From COVID-19 to Sarcoidosis: How Similar Are These Two Diseases?

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.877303

DOI=10.3389/fimmu.2022.877303

ISSN=1664-3224

ABSTRACT=The outbreak of COVID-19 is caused by the infection of SARS-CoV-2, which leads to the disruption of immune system, exacerbated inflammation, and even multiple organ dysfunction syndrome. Sarcoidosis characterized by compact, epithelioid, non-necrotizing lesions with varying degrees of lymphocytic inflammation, is an idiopathic granulomatous multisystem disease. These two diseases not only have similarities in clinical manifestations, but may also influence each other and affect their clinical courses. We analyzed some possible connections between sarcoidosis and COVID-19, including the role of the RAS in the respiratory system, immune response, and cell death pathways to understand potential mechanisms predisposing individuals to severe forms of SARS-CoV-2 infection and provide a new prospect for the treatment of COVID-19 and an opportunity to better understand the pathogenesis of sarcoidosis.