AUTHOR=Bu Jin , Ding Ruilian , Zhou Liangjia , Chen Xiangming , Shen Erxia 

TITLE=Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.880201

DOI=10.3389/fimmu.2022.880201

ISSN=1664-3224

ABSTRACT=Psoriasis is a chronic autoimmune inflammatory disease that remains active for a long period even lifetime in most patients. The impact of psoriasis on health is not only limited to the skin, but also influences multiple systems of the body, even mental health. With the increasing of literature on association between psoriasis and extracutaneous systems, a better understanding of psoriasis as an autoimmune disease with systemic inflammation is created. Except of cardiometabolic diseases, gastrointestinal diseases, chronic kidney diseases, malignancy, infections that have received much attention, the association between psoriasis and more systemic diseases, including skin system, reproductive system, oral and ocular systems, has also been revealed, and mental health diseases draw more attention not just because of the mental and mood negative influence caused by skin lesions, but a common immune-inflammatory mechanism identified of the two systemic diseases. This review summarizes the epidemiological evidence supporting the association between psoriasis and important and/or new-reported systemic diseases in the past five years, and may help to comprehensively recognize the comorbidity burden related to psoriasis, further to improve the management on the persons with psoriasis.