AUTHOR=Zhao Jianan , Wei Kai , Jiang Ping , Chang Cen , Xu Lingxia , Xu Linshuai , Shi Yiming , Guo Shicheng , Xue Yu , He Dongyi 

TITLE=Inflammatory Response to Regulated Cell Death in Gout and Its Functional Implications

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.888306

DOI=10.3389/fimmu.2022.888306

ISSN=1664-3224

ABSTRACT=Gout is a chronic inflammatory arthritis disease characterized by hyperuricemia and is caused by interactions between genetics, epigenetics, and metabolism. Acute gout symptoms are triggered by the inflammatory response to monosodium urate crystals, which is mediated by the innate immune system and immune cells (e.g., macrophages and neutrophils), NLRP3 inflammasome activation, and pro-inflammatory cytokine (IL-1β) release. Recent studies indicated that multiple programmed cell death pathways are involved in the inflammatory response, including pyroptosis, NETosis, necroptosis, and apoptosis, to initiate inflammatory reactions. In this review, we explore the correlation and interactions among these factors and their roles in the pathogenesis of gout to provide future research directions and possibilities for identifying potential novel therapeutic targets and enhancing the understanding of the pathogenesis of gout.