AUTHOR=Simard Mélissa , Morin Sophie , Ridha Zainab , Pouliot Roxane 

TITLE=Current knowledge of the implication of lipid mediators in psoriasis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.961107

DOI=10.3389/fimmu.2022.961107

ISSN=1664-3224

ABSTRACT=The skin is an organ involved in several biological processes essential to the organism’s proper functioning. Bioactive lipid mediators, derived from polyunsaturated fatty acids (PUFAs), constitute a complex bioactive lipid network greatly involved in skin homeostasis. Bioactive lipid mediators derived from n-3 and n-6 PUFAs have well-documented anti- and pro-inflammatory properties, and are recognized as playing numerous and complex roles in the behaviour of diverse skin diseases, including psoriasis. Studies have shown that a high intake of n-3 PUFAs can influence the development and progression of psoriasis, mainly by reducing the severity and frequency of psoriatic plaques. Herein, we provide an overview of the differential effects of n-3 and n-6 PUFAs lipid mediators and their distinct implications in the skin, particularly in psoriasis. This review summarizes current findings on lipid mediators playing a role in skin and their potential as therapeutic targets for psoriatic patients.