AUTHOR=Wang Shuang , Yu Xiao-juan , Li Dan-yang , Xu Jin , Wang Su-xia 

TITLE=Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.966591

DOI=10.3389/fimmu.2022.966591

ISSN=1664-3224

ABSTRACT=Leukocyte chemotactic factor 2-associated (ALECT2) amyloidosis is one of the recently reported types of amyloidosis which is caused by the extracellular deposition of leukocyte chemotactic factor 2 (LECT2). There have not been any reports involved the concurrent of ALECT2 amyloidosis with Sjögren’s syndrome (SS) or systemic lupus erythematosus (SLE) previously. Herein, we report a case of 68-year-old Chinese woman presenting with long duration of sicca symptoms. The clinical evaluation and laboratory findings showed she had SS overlapped with SLE. Kidney biopsy revealed a membranoproliferative glomerulonephritis (MPGN) with glomerular deposition of dominant IgG3-kappa by immunofluorescene, which was related to SS/SLE. Furthermore, patchy of congophilic amyloid deposits in the tubulointerstitium were detected, which were positive for LECT2 protein by immunohistochemical staining and immunoelectron microscopy. This is the first case of ALECT2 amyloidosis coexisted with SS/SLE, and the causal relationship between ALECT2 amyloidosis and autoimmune diseases remained unclear.