AUTHOR=Mesquita Tirza Gabrielle Ramos de , Junior José do Espírito Santo , Silva Luan Diego Oliveira da , Silva George Allan Villarouco , Araújo Felipe Jules de , Pinheiro Suzana Kanawati , Kerr Herllon Karllos Athaydes , Silva Lener Santos da , Souza Luciane Macedo de , Almeida Samir Assad de , Queiroz Krys Layane Guimarães Duarte , Souza Josué Lacerda de , Silva Cilana Chagas da , Sequera Héctor David Graterol , Souza Mara Lúcia Gomes de , Barbosa Anderson Nogueira , Pontes Gemilson Soares , Guerra Marcus Vinitius de Farias , Ramasawmy Rajendranath TITLE=Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis JOURNAL=Frontiers in Immunology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.974051 DOI=10.3389/fimmu.2022.974051 ISSN=1664-3224 ABSTRACT=

The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity. A comparison of systemic immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals with the same socio-epidemiological characteristics coming from the same endemic areas as the patients is performed to identify particular immune profile and pathways associated with the progression of disease development. Twenty-seven plasma soluble circulating factors were evaluated between the groups by univariate and multivariate analysis. The following biomarkers pairs IL-17/IL-9 (ρ=0,829), IL-17/IL-12 (ρ=0,786), IL-6/IL-1ra (ρ=0,785), IL-6/IL-12 (ρ=0,780), IL-1β/G-CSF (ρ=0,758) and IL-17/MIP-1β (ρ=0,754) showed the highest correlation mean among the patient while only INF-γ/IL-4 (ρ=0.740), 17/MIP-1β (ρ=0,712) and IL-17/IL-9 (ρ=0,707) exhibited positive correlation among the control group. The cytokine IL-17 and IL1β presented the greater number of positive pair correlation among the patients. The linear combinations of biomarkers displayed IP-10, IL-2 and RANTES as the variables with the higher discriminatory activity in the patient group compared to PDGF, IL-1ra and eotaxin among the control subjects. IP-10, IL-2, IL-1β, RANTES and IL-17 seem to be predictive value of progression to the development of disease among the Lg-infected individuals.