AUTHOR=Zhang Wenqi , Huang Chen , Liu Ruixia , Zhang Huichao , Li Weijing , Yin Shaoning , Wang Lianjing , Liu Wei , Liu Lihong 

TITLE=Case report: CD19-directed CAR-T cell therapy combined with BTK inhibitor and PD-1 antibody against secondary central nervous system lymphoma

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.983934

DOI=10.3389/fimmu.2022.983934

ISSN=1664-3224

ABSTRACT=Secondary central nervous system lymphoma (SCNSL) has grave prognosis and high mortality. Current therapeutic strategies for central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) were extremely limited. This report describes a young female patient with DLBCL and CNS relapse, who received low-dose CD19-CAR-T therapy followed by BTK inhibitor and PD-1 antibody after several lines of chemotherapy. There were limited reports on CAR-T therapy applied for SCNSL, particularly those in combination with targeted agents. The current treatment combination for this case provides a new regimen for CNS relapse from DLBCL.