AUTHOR=Liu Lili , Chen Juanjuan , Zhang Yue , Wu Jun , Hu Jun , Lin Zhijian 

TITLE=Case report: Immunoadsorption therapy for anti-caspr1 antibody-associated nodopathy

JOURNAL=Frontiers in Immunology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.986018

DOI=10.3389/fimmu.2022.986018

ISSN=1664-3224

ABSTRACT=Several autoantibodies against proteins located at nodes of Ranvier have been identified in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) in the last few years (1). These autoantibodies include anti-neurofascin, anti-contactin1 (CNTN1), and anti-contactin-associated protein 1 (Caspr1) antibodies.Nodo-paranodopathies are a recently classified group of diseases with autoantibodies against node of Ranvier proteins. In our case report, we describe a patient with anti-Caspr1 antibody-associated nodopathy who achieved a good response to immunoadsorption therapy.This case expands our understanding of anti-Caspr1 antibody-associated nodopathies and provides evidence for IA therapy in these diseases.