AUTHOR=ElAbd Hesham , Bacher Petra , Tholey Andreas , Lenz Tobias L. , Franke Andre TITLE=Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins JOURNAL=Frontiers in Immunology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1107266 DOI=10.3389/fimmu.2023.1107266 ISSN=1664-3224 ABSTRACT=
The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA region, implying an important role for specific HLA-presented peptides in the etiology of these diseases. Identifying the specific set of peptides presented by an individual’s HLA proteins