AUTHOR=Zhao Kelin , Kong Chenfei , Shi Naixu , Jiang Jinlan , Li Ping 

TITLE=Potential angiogenic, immunomodulatory, and antifibrotic effects of mesenchymal stem cell-derived extracellular vesicles in systemic sclerosis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1125257

DOI=10.3389/fimmu.2023.1125257

ISSN=1664-3224

ABSTRACT=Systemic sclerosis (SSc) is an intricate systemic autoimmune disease with pathological features such as vascular injury, immune dysregulation, and the extensive fibrosis of skin and multiple organs. Its treatment options are limited. In the past few years, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been widely acknowledged in preclinical and clinical trials as being useful in treating autoimmune diseases and are likely superior to MSCs. Recent researches have also shown that MSC-EVs can improve SSc and pathological changes in vasculopathy, immune dysfunction, and fibrosis. This review summarizes the therapeutic effects of MSC-EVs on SSc and the mechanisms that have been discovered to provide a theoretical basis for future studies on the role of MSC-EVs in treating SSc.