AUTHOR=Zhou Qiujun , Wei Shenyu , Wang Hui , Li Yuanyuan , Fan Shasha , Cao Yi , Wang Chenglei 

TITLE=T cell-derived exosomes in tumor immune modulation and immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1130033

DOI=10.3389/fimmu.2023.1130033

ISSN=1664-3224

ABSTRACT=Exosomes are nanoscale vesicles secreted by most cells that have a phospholipid bilayer structure. Exosomes contain DNA, small RNA (sRNA), proteins and other substances, which can carry proteins and nucleic acids and participate in the communication between cell. T cells are an indispensable part of adaptive immunity, and the functions of T cell-derived exosomes have been widely studied. In the more than three decades since the discovery of exosomes, several studies have revealed that T cell-derived exosomes play a novel role in cell-to-cell signaling, especially in tumor immune response. In this review, we will review the function of exosomes derived from different T cell subsets, explore applications in tumor immunotherapy and consider the associated challenges.