AUTHOR=Tu Zhixin , Wang Yao , Wang Yan , Huang Jianjie , Han Yujin , Ji Qijia , Cao Xiaoxuan , Wen Xiaoyu , Wang Yang , Jin Qinglong 

TITLE=TR score: A noninvasive model to predict histological stages in patients with primary biliary cholangitis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1152294

DOI=10.3389/fimmu.2023.1152294

ISSN=1664-3224

ABSTRACT=The aim of this study was to develop a noninvasive prediction model for histological stages in PBC that is simple, easy to implement, and highly accurate. A total of 114 patients with PBC were included in this study, randomly divided into a model group (n=78) and a validation group (n=36). Demographic, laboratory data and histological assessments were collected. 23 noninvasive models were calculated. This study included 99 females (86.8%) and 15 males (13.2%). The number of patients in Scheuer’s stage 1, 2, 3 and 4 was 33 (29.0%), 34 (29.8%), 16 (14.0%), and 31 (27.2%), respectively. TBA and RDW are independent predictors of PBC histological stages and are helpful to distinguish patients with different stages. When predicting early histological lesions (S1) or liver fibrosis and cirrhosis (S3-S4), the AUROCs of TR score were 0.887 (95% CI, 0.809-0.965) and 0.893 (95% CI, 0.816-0.969), higher than all of the other 22 models included in this study. When predicting cirrhosis (S4), its AUROC is still as high as 0.921 (95% CI, 0.837-1.000). In conclusion, the TR score is an easy, cheap and stable noninvasive model, without complex calculation formulas and tools, and shows good accuracy in diagnosing the histological stages of PBC.