AUTHOR=Li Laifu , Dai Fei , Wang Lianli , Sun Yating , Mei Lin , Ran Yan , Ye Fangchen 

TITLE=CCL13 and human diseases

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1176639

DOI=10.3389/fimmu.2023.1176639

ISSN=1664-3224

ABSTRACT=CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many immune cells. Despite extensive investigations into its role in various disorders, a comprehensive review of CCL13 is currently unavailable. In this review, we summarize the involvement of CCL13 in human disorders and the CCL13-centered treatments that have been developed. The role of CCL13 in rheumatic diseases, skin diseases, and cancer is relatively well-established, with some reports indicating its involvement in ocular disorders, orthopedic diseases, nasal polyps, and obesity. We also provide an overview of studies that reported minimal CCL13-related findings in HIV, nephritis, and multiple sclerosis. Although CCL13-mediated inflammation is often implicated in disease pathogenesis, interestingly, it may play a protective role in certain diseases such as primary biliary cholangitis (PBC) and suicide.