AUTHOR=Botía-Sánchez María , Galicia Georgina , Albaladejo-Marico Lorena , Toro-Domínguez Daniel , Morell Maria , Marcos-Fernández Raquel , Margolles Abelardo , Alarcón-Riquelme Marta E. 

TITLE=Gut epithelial barrier dysfunction in lupus triggers a differential humoral response against gut commensals

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1200769

DOI=10.3389/fimmu.2023.1200769

ISSN=1664-3224

ABSTRACT=Systemic lupus erythematosus is an autoimmune disease with multisystemic involvement including intestinal inflammation. Lupus-associated intestinal inflammation may alter the mucosal barrier where millions of commensals have a dynamic and selective interaction with the host immune system. Here, we investigated the consequences of the intestinal inflammation in a TLR7-mediated lupus model. We found that lupus-associated intestinal inflammation modifies the IgA+ B cell response in the gut-associated lymphoid tissue in association with dysbiosis. Intestinal inflammation also alters the tight junction protein expression in the epithelial barrier, which correlates with increased paracellular permeability of the intestinal barrier. This permeability resulted in a differential systemic humoral response against intestinal commensals.