AUTHOR=Roland Mary Melissa , Peacock Tori E. , Hall Nia , Mohammed Ahmed Dawood , Ball Ryan , Jolly Amy , Alexeev Sergei , Dopkins Nicolas , Nagarkatti Mitzi , Nagarkatti Prakash , Kubinak Jason L. 

TITLE=B-cell-specific MhcII regulates microbiota composition in a primarily IgA-independent manner

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1253674

DOI=10.3389/fimmu.2023.1253674

ISSN=1664-3224

ABSTRACT=MhcII-mediated coordination of cellular interactions determines the capacity of an individual's adaptive immune response to serve as a force of natural selection regulating microbial ecology in the gut. However, despite representing more than 95% of the MhcII-expressing cells in secondary lymphoid tissues (SLOs), direct assessment of the role of B-cell-specific MhcII signaling in the regulation of gut microbial ecology has not been empirically tested. Here, we present the results of a novel Rag1 -/-adoptive transfer model our group has developed to address this gap in our knowledge. Results from our experiments demonstrate that B-cell-specific MhcII regulates phylogenetic composition, species abundance, and species richness in gut microbial communities. However, contrary to expectations, this effect appears to be primarily driven in an IgA-independent manner.