AUTHOR=Martínez-Sanz Javier , Talavera-Rodríguez Alba , Díaz-Álvarez Jorge , Rosas Cancio-Suárez Marta , Rodríguez Juan Miguel , Alba Claudio , Montes María Luisa , Martín-Mateos Rosa , Burgos-Santamaría Diego , Moreno Santiago , Serrano-Villar Sergio , Sánchez-Conde Matilde 

TITLE=A gut microbiome signature for HIV and metabolic dysfunction-associated steatotic liver disease

JOURNAL=Frontiers in Immunology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1297378

DOI=10.3389/fimmu.2023.1297378

ISSN=1664-3224

ABSTRACT=homogeneity across individuals, in contrast to that observed in the HIV+NAFDL-group, in which the dispersion was higher (Permanova test, p value <0.001; ANOSIM, p value <0.001). MASLD but not HIV determined a different microbiota structure (HIV +MASLD-vs.HIV + MASLD + , q-value = 0.002; HIV -MASLD + vs. HIV + MASLD + , q-value = 0.930; and HIV - MASLD + vs. HIV + MASLD -, q-value < 0.001). The most abundant genera in MASLD-were Prevotella, Bacteroides, Dialister, Acidaminococcos, Alloprevotella, andCatenibacterium. In contrast, the most enriched genera in MASLD+ were Ruminococcus, Streptococcus, Holdemanella, Blautia, and Lactobacillus.We found a microbiome signature linked to MASLD, which had a greater influence on the overall structure of the gut microbiota than HIV status alone.