AUTHOR=Shang Weifeng , Zhang Sheng , Qian Hang , Huang Sisi , Li Hui , Liu Jiao , Chen Dechang 

TITLE=Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1266230

DOI=10.3389/fimmu.2024.1266230

ISSN=1664-3224

ABSTRACT=It is unclear what the causal relationship is between the gut microbiota and sepsis. Therefore, we employed MR to determine whether a causal link exists between the two.Methods: This study used publicly available GWAS summary data of gut microbiota, sepsis, sepsis (critical care), and sepsis (28-day death in critical care) to perform a two-sample MR analysis. To ensure the robustness of the results, we also conducted a sensitivity analysis.Results: For sepsis susceptibility, IVW estimates revealed Victivallales (OR= 0.86, 95%CI, 0.78-0.94, P = 0.0017) was protective against sepsis.While, Lentisphaerae (OR=0.89, 95% CI, 0.80-0.99),