AUTHOR=Zhang Ling , Li Haifeng , Wang Tao , Wang Zhu , Wu Yang , Guo Siquan , Li Wenjing , Zhou Yeru , Xue Haixiang , You Jianqiang 

TITLE=Association between peripheral eosinophilia, JESREC score, and olfactory dysfunction in patients with chronic rhinosinusitis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1334656

DOI=10.3389/fimmu.2024.1334656

ISSN=1664-3224

ABSTRACT=The purpose was to evaluate the relationship between peripheral eosinophilia, JESREC score and olfactory dysfunction in chronic rhinosinusitis (CRS) patients and to explore the accuracy and specific cut-points of the JESREC score in predicting olfactory dysfunction.In this cross-sectional, retrospective study, olfactory function was assessed by the Sniffin' Sticks 12-item test and multivariate logistic regression analyses were applied. Receiver operating characteristics curves were performed to derive accuracy and cutoff values for the JESREC scores of olfactory dysfunction criterion.Results: A total of 354 patients (mean [SD] age, 50.0 [14.9] years; 41.8% women) were included in the finally analysis. The prevalence of olfactory dysfunction was 46.3%. Individuals who had olfactory dysfunction were more likely to be male (64.6% vs. 52.6%), ECRS (39.0% vs. 7.9%), longer course (2.3 vs. 1.5 years), higher JESREC scores (8.5 vs. 4.5) and had higher proportion of nasal polyps (78.7% vs. 18.9%) and peripheral eosinophilia (3.3% vs. 1.4%). In logistic analysis,